Diazoxide in Children With Obesity After Hypothalamic-Pituitary Lesions: A Randomized, Placebo-Controlled Trial.

Objective: The objective was to evaluate the safety and efficacy of diazoxide (DZX) for decreasing obesity with hyperinsulinemia in patients treated for hypothalamic-pituitary lesions during childhood.

Design: This was a double-blind, placebo-controlled trial in parallel groups using a centralized randomization process (PEDIAC).

Setting: This was a single-center study.

Premature pubarche before one year of age: distinguishing between mini-puberty variants and precocious puberty.

Background: The aim of this study was to facilitate the distinction between the benign "mini-puberty of early infancy" and precocious puberty (PP).

Material And Methods: We compared 59 patients (21 boys and 38 girls) seen for pubic hair development before one year of age diagnosed as mini-puberty to 13 patients (2 boys) in whom pubertal development before one year revealed a PP.

Results: The boys with mini-puberty presented with pubic hair development and prepubertal testicular volume, with low plasma testosterone concentrations.

Congenital hypogonadotropic hypogonadism during childhood: presentation and genetic analyses in 46 boys.

Background: The majority of the patients reported with mutations in isolated hypogonadotropic hypogonadism (HH) are adults. We analysed the presentation and the plasma inhibin B and anti-müllerian hormone (AMH) concentrations during childhood and adolescence, and compared them to the genetic results.

Methods: This was a retrospective, single-center study of 46 boys with HH.