Anti-HPV16 E2 protein T-cell responses and viral control in women with usual vulvar intraepithelial neoplasia and their healthy partners.

T-cell responses (proliferation, intracellular cytokine synthesis and IFNγ ELISPOT) against human papillomavirus 16 (HPV16) E2 peptides were tested during 18 months in a longitudinal study in eight women presenting with HPV16-related usual vulvar intraepithelial neoplasia (VIN) and their healthy male partners. In six women, anti-E2 proliferative responses and cytokine production (single IFNγ and/or dual IFNγ/IL2 and/or single IL2) by CD4+ T lymphocytes became detectable after treating and healing of the usual VIN. In the women presenting with persistent lesions despite therapy, no proliferation was observed.

Non-sexually related acute genital ulcers in 13 pubertal girls: a clinical and microbiological study.

Objective: To describe the clinical and microbiological features of acute genital ulcers (AGU), which have been reported in virgin adolescents, predominantly in girls.

Design: Descriptive study. We collected data on the clinical features, sexual history, blood cell count, biochemistry, microbiological workup, and 1-year follow-up.

A randomized prospective trial of the cutaneous and sensory effects of feminine hygiene wet wipes.

Objective: To assess the effects of feminine hygiene wet wipes on vulvar skin.

Study Design: An examiner-blind, randomized, prospective clinical trial of prototype wet wipes (treatment group) and dry toilet tissue (comparison group) in 120 premenopausal and 60 postmenopausal women was conducted in which the wipes or toilet tissues were for approximately 28 consecutive days.

Results: Use of wet wipes in lieu of toilet tissue caused no significant impact on erythema of the external genitalia.

Local relapse in patients treated for squamous cell vulvar carcinoma: incidence and prognostic value.

To evaluate the risk factors for local relapse in vulvar cancer patients and its impact on survival as a function of its different patterns, which include local recurrences at the primary tumor site, recurrences remote from the primary tumor, and skin bridge recurrences. Between January 1978 and June 1999, 215 patients were treated for vulvar squamous cell carcinoma. The median follow-up was 38 months.

Perineoplasty for the treatment of introital stenosis related to vulvar lichen sclerosus.

Objective: The objective of this study is to assess the usefulness of perineoplasty for introital stenosis related to vulvar lichen sclerosus.

Study Design: The records of 64 patients who underwent perineoplasty for this indication were reviewed retrospectively. The median age of patients was 49 years, and the median duration of lichen sclerosus was 60 months.