Publications by authors named "Monique C de Oliveira"
Redescription of Raillietiella mottae (Raillietiellidae: Pentastomida) a generalist parasite of insectivorous lizards: phenotypic plasticity revealed by molecular data.
Parasitol Res
October 2024
Article Synopsis
- Pentastomida are lung parasites primarily found in reptiles, with the genus Raillietiella having the most species but still mostly identified through physical traits.
- The Raillietiella parasites are categorized into morphotypic groups, with differences in hook shapes among species, like sharp versus blunt tips.
- This study used molecular analysis to show that what seems like morphological differences in Raillietiella mottae is actually a phenotypic variation linked to the host species, with female size and hook shape varying based on whether the lizards are nocturnal or diurnal.
Cerebral ischemia-induced hyperglycemia has been reported to accentuate neurological damage following focal or global cerebral ischemia. Hyperglycemia found in rats following focal brain ischemia occurs in the first 24 h and has been claimed to be caused by increased liver gluconeogenesis and insulin resistance. However, liver gluconeogenesis and the mechanisms leading to hyperglycemia after global cerebral ischemia remain uncertain.
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- Severe rheumatoid cachexia leads to notable loss of muscle and fat mass in advanced rheumatoid arthritis patients, increasing the risk of cardiovascular diseases.
- Circulating levels of triglycerides (TG) and free fatty acids (FFA) are not well-defined in severe arthritis, prompting a study to explore lipid profiles and liver metabolism in arthritic rats.
- Findings show reduced TG and cholesterol levels in the serum and liver of arthritic rats, alongside higher FFA levels, indicating alterations in lipid metabolism driven by increased oxidation and reduced fatty acid synthesis in the arthritic liver.
Unlabelled: Menopause is often followed by obesity and, related to this, non-alcoholic fatty liver disease (NAFLD). Two bile acid (BA) receptors, farnesoid X receptor (FXR) and G-protein-coupled receptor TGR5, have emerged as putative therapeutic targets for obesity and NAFLD.
Aim Of This Study: to evaluate the efficacy of selective agonists INT747/obeticholic acid (FXR) and INT777 (TGR5) as novel treatments for the metabolic effects of oestrogen deficiency.
Liver mitochondrial function and redox status in an experimental model of non-alcoholic fatty liver disease induced by monosodium L-glutamate in rats.
Exp Mol Pathol
December 2011
Article Synopsis
- The study aimed to explore the role of mitochondrial dysfunction in non-alcoholic fatty liver disease (NAFLD) using a rat model of obesity induced by monosodium L-glutamate (MSG).
- Results showed that liver mitochondria from these obese rats had increased fatty acid β-oxidation and oxidising capacity for succinate without impairing oxidative phosphorylation efficiency.
- The overall findings suggested that mitochondrial dysfunction does not contribute to liver fat accumulation in this model, and enhancements in specific enzyme activities may help defend against oxidative stress.
Tibolone is a synthetic steroid that has been extensively prescribed to treat climacteric symptoms and to prevent postmenopausal osteoporosis. Because menopause is a condition associated with increased incidence of metabolic disturbances and hepatic steatosis, the aim of this work was to evaluate the actions of tibolone on the liver. The effects of tibolone on glucose and fatty acid metabolism and on several parameters linked to mitochondrial energy metabolism, including the induction of cellular oxidative stress, were investigated in livers from female Wistar rats.
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- The study examines how fat accumulation in the liver affects calcium movement and the liver's response to the hormone phenylephrine in obese rats.
- Researchers used rats with MSG-induced obesity to analyze calcium uptake in liver cells, finding reduced calcium absorption in the livers of obese rats due to decreased enzyme activity.
- Despite having similar glycogen levels, obese rat livers released more glucose in reaction to phenylephrine, suggesting altered metabolic responses linked to higher intracellular calcium levels.