Determination of bisphosphonate properties in terms of bioavailability, bone affinity, and cytotoxicity.

Background: The study aimed to evaluate the therapeutic potential of fourteen newly synthesized bisphosphonates by assessing their bioavailability, bone affinity, and cytotoxicity. These bisphosphonates included a series of aminomethylenebisphosphonates and standard compounds such as risedronate and tiludronate.

Methods: Drug permeability was determined using Parallel Artificial Membrane Permeability Assays (PAMPA), while bone affinity was assessed by sorption on hydroxyapatite.

Development and Validation of Computational Fluid Dynamics Model of Ladle Furnace with Electromagnetic Stirring System.

Numerical methods are crucial to supporting the development of new technology in different industries, especially steelmaking, where many phenomena cannot be directly measured or observed under industrial conditions. As a result, further designing and optimizing steelmaking equipment and technology are not easy tasks. At the same time, numerical approaches enable modeling of various phenomena controlling material behavior and, thus, understanding the physics behind the processes occurring in different metallurgical devices.

Release of drugs used in the treatment of osteoporosis from zeolites with divalent ions-Influence of the type of ion and drug on the release profile.

Bisphosphonates are drugs that are used to treat osteoporosis that causes the low mineral density of the bones. These drugs can be delivered in several ways, but each method has disadvantages. Materials with high potential as carriers of these drugs are zeolites with divalent ions.

The Effects of Various Food Products on Bisphosphonate's Availability.

The bioavailability of orally administered bisphosphonates is very low (<1%) due to their short absorption window in the proximal duodenum and high affinity for food. Food ingredients are able to bind the drug, but the presence of food extends the residence time of bisphosphonates in the absorption window. Therefore, the main goal of this study is to select a group of food products that are characterized by low binding affinity to bisphosphonates and thus will not reduce their availability upon concomitant administration.

Imaging of Increasing Damage in Steel Plates Using Lamb Waves and Ultrasound Computed Tomography.

This paper concerns the inspection of steel plates, with particular emphasis on the assessment of increasing damage. Non-destructive tests were performed on four plates, one of which was undamaged, while the remaining three had defects in the form of circular holes with diameters of 2, 5 and 10 cm. Guided Lamb waves were used in the research, and the image reconstruction was performed using ultrasound computed tomography.

Controlled release of the drug for osteoporosis from the surface of titanium implants coated with calcium titanate.

The most popular drugs used to prevent osteoporosis that causes low mineral density and weakened microstructure of bones are bisphosphonates. Bisphosphonates can be administered in several ways, but each delivery method has drawbacks. Due to this, new methods of their delivery are being sought.

Determination of bisphosphonates anti-resorptive properties based on three forms of ceramic materials: Sorption and release process evaluation.

There is a strong need to search for more effective compounds with bone anti-resorptive properties, which will cause fewer complications than commonly used bisphosphonates. To achieve this goal, it is necessary to search for new techniques to characterize the interactions between bone and drug. By studying their interaction with hydroxyapatite (HA), this study used three forms of ceramic materials, two of which are bone-stimulating materials, to assess the suitability of new active substances with anti-resorptive properties.

Past, present, and future geographic range of the relict Mediterranean and Macaronesian complex.

Aim: The aim of this study is to model the past, current, and future distribution of ., , and , based on bioclimatic variables using a maximum entropy model (Maxent) in the Mediterranean and Macaronesian regions.

Location: Mediterranean and Macaronesian.

Dietary and Lifestyle Changes During COVID-19 and the Subsequent Lockdowns among Polish Adults: A Cross-Sectional Online Survey PLifeCOVID-19 Study.

The present study aimed to identify patterns of dietary changes during the COVID-19 pandemic and their associations with sociodemographics, body mass index (BMI) before pandemic, and lifestyle changes in Polish adults and to examine the effects of lockdowns on dietary-lifestyle changes. This study used a cross-sectional online survey to collect data. The -means algorithm was used to determine of patterns of dietary changes, and logistic regression analyses were performed.

The Use of Added Salt and Sugar in the Diet of Polish and Austrian Toddlers. Associated Factors and Dietary Patterns, Feeding and Maternal Practices.

Children aged <2 years should not be given meals with the addition of salt and sugar due to health risks and to promote healthier dietary habits. The aims of this study were: to assess the prevalence of the use of added salt (AS), sugar (ASu) and both salt and sugar (AS&Su) in the diets of Polish and Austrian toddlers aged 12-24 and 25-36 months; to explore the sociodemographic and early nutritional factors associated with the use of AS and ASu; to investigate the difference in dietary habits and maternal concerns about toddlers' eating regarding the use of AS and ASu in toddlers' diet. This cross-sectional anonymous study was conducted in 5893 mothers of children aged 12-36 months, recruited through social media in 2017-2019.

A novel open source tool for ELISA result analysis.

ELISA has become a standard analytical tool in the numerous branches of science and industry. Processing of the ELISA results may be a multistep process, often requiring a prior adaptation, using proprietary software, or exporting the results into external internet platforms. It may be problematic in the light of good documentation practices and maintaining good data integrity.

Integrated Application of GPR and Ultrasonic Testing in the Diagnostics of a Historical Floor.

The paper presents the results of integrated ground penetrating radar (GPR) and ultrasonic testing (UT) measurements conducted on a historical floor in St. Nicholas' Church, Gdańsk, Poland. The described inspection was the first stage of the technical state assessment of the building.

Analysis of Association between Breastfeeding and Vegetable or Fruit Intake in Later Childhood in a Population-Based Observational Study.

Vegetable and fruit consumption in childhood remains below recommendations in many countries. As the intake of fruit and/or vegetables during childhood in a few studies was associated with breastfeeding, it may be suggested as a serious interfering factor while analyzing the association between breastfeeding and its long-term health effects. Thus, it may be important for creation and implementation of effective public health programs.

Calcium zeolites as intelligent carriers in controlled release of bisphosphonates.

This work describes the synthesis of calcium zeolites (type A and X) and their use as drug carriers. This is the first example of using calcium zeolites as intelligent carriers that release drugs under the influence of body fluids. Both zeolites and zeolite/drug systems have been extensively characterized.

Protective Effect of Breastfeeding on the Adverse Health Effects Induced by Air Pollution: Current Evidence and Possible Mechanisms.

Air pollution is a major social, economic, and health problem around the world. Children are particularly susceptible to the negative effects of air pollution due to their immaturity and excessive growth and development. The aims of this narrative review were to: (1) summarize evidence about the protective effects of breastfeeding on the adverse health effects of air pollution exposure, (2) define and describe the potential mechanisms underlying the protective effects of breastfeeding, and (3) examine the potential effects of air pollution on breastmilk composition and lactation.

Factors Influencing the Age of Complementary Feeding-A Cross-Sectional Study from Two European Countries.

The timing of introducing complementary feeding affects nutritional status and children's health. The aim of this study was to determine sociodemographic and birth-related factors associated with the age of introducing complementary foods. This cross-sectional study investigated parents ( = 5815) of children aged 12-36 months from Poland ( = 4065) and Austria ( = 1750) using a single online questionnaire.

Lipid Profile, Lipase Bioactivity, and Lipophilic Antioxidant Content in High Pressure Processed Donor Human Milk.

Human milk fat plays an essential role as the source of energy and cell function regulator; therefore, the preservation of unique human milk donors' lipid composition is of fundamental importance. To compare the effects of high pressure processing (HPP) and holder pasteurization on lipidome, human milk was processed at 62.5 °C for 30 min and at five variants of HPP from 450 MPa to 600 MPa, respectively.

Association between Breastmilk LC PUFA, Carotenoids and Psychomotor Development of Exclusively Breastfed Infants.

The first months of infant life are crucial for proper neurodevelopment, which may be influenced by several factors, including nutrition and nutrients (e.g., long-chain polyunsaturated fatty acids (LC PUFA) and carotenoids) of which the concentration in breastmilk is diet-dependent.

Carotenoid Content in Breastmilk in the 3rd and 6th Month of Lactation and Its Associations with Maternal Dietary Intake and Anthropometric Characteristics.

Carotenoids are diet-dependent milk components that are important for the visual and cognitive development of an infant. This study determined β-carotene, lycopene and lutein + zeaxanthin in breastmilk and its associations with dietary intake from healthy Polish mothers in the first six months of lactation. Concentrations of carotenoids in breastmilk were measured by HPLC (high-performance liquid chromatography) (first, third, sixth month of lactation) and dietary intake was assessed based on a three-day dietary record (third and sixth month of lactation).

Non-Destructive Assessment of Masonry Pillars using Ultrasonic Tomography.

In this paper, a condition assessment of masonry pillars is presented. Non-destructive tests were performed on an intact pillar as well as three pillars with internal inclusions in the form of a hole, a steel bar grouted by gypsum mortar, and a steel bar grouted by cement mortar. The inspection utilized ultrasonic stress waves and the reconstruction of the velocity distribution was performed by means of computed tomography.

Zeolite fillers for resin-based composites with remineralizing potential.

The objective of the study is to obtain the modified zeolite powders and to apply these materials as active fillers in the dental composites with the remineralizing potential. Three different synthesis pathways were applied to receive LTA-type (Linde A-type) zeolites. All zeolites were subjected to the ion exchange process and mineralization of surface with hydroxyapatite (HA) layer.

The combined effects of alcohol and tobacco use during pregnancy on birth outcomes.

Background: Exposure to alcohol and tobacco during pregnancy may lead to developmental disorders in the foetus and can also adversely impact pregnancy outcomes and the newborn’s health status.

Objective: Assessment of alcohol consumption and tobacco use during pregnancy as well as their impact on pregnancy outcomes and birth parameters of the newborn in a selected group of mothers with children aged ≤ 2 years.

Material And Methods: The study was conducted in 104 mothers with children aged ≤ 2 years living in the Mazowiecki Voivodeship.

Characteristics of the regional human milk bank in Poland - donors, recipients and nutritional value of human milk.

Background: In case of shortage of breast milk despite proper lactation care or the poor state of the mother’s health, breast milk from human milk bank is recommended for feeding preterm infants

Objective: This study retrospectively evaluated the first year of the operation of the Regional Human Milk Bank

Material And Methods: Data concerning donors was collected in the human milk bank during the cooperation. The clinical characteristics of the recipients was made on the basis of medical documentation from the Holy Family Hospital in Warsaw, Poland. Analysis of nutritional value was performed with the human milk analyzer (MIRIS AB)

Results: In the first year of activity, 45 voluntary donors established cooperation, donating from 650 to 32030 ml of human milk.

Reasons for non-exclusive breast-feeding in the first 6 months.

Background: Maternal sociodemographic, delivery- and infant-related factors as well as hospital practice are relevant for breast-feeding practice. The aim of this study was to identify the sociodemographic and delivery-related factors that may affect exclusive breast-feeding (EBF) of infants aged 0-6 months in Poland.

Methods: A total of 446 mothers (18-42 years old) of infants aged 0-6 months were interviewed using the computer-assisted Web interview method.

Health Effects of Carotenoids during Pregnancy and Lactation.

Adequate nutrition is particularly important during pregnancy since it is needed not only for maintaining the health of the mother, but also determines the course of pregnancy and its outcome, fetus development as well as the child's health after birth and during the later period of life. Data coming from epidemiological and interventions studies support the observation that carotenoids intake provide positive health effects in adults and the elderly population. These health effects are the result of their antioxidant and anti-inflammatory properties.