Role of metal(ii) hexacyanocobaltate(iii) surface chemistry for prebiotic peptides synthesis.

Double metal cyanide (DMC), a heterogeneous catalyst, provides a surface for the polymerization of amino acids. Based on the hypothesis, the present study is designed to evaluate favorable environmental conditions for the chemical evolution and origin of life, such as the effects of temperature and time on the oligomerization of glycine and alanine on metal(ii) hexacyanocobaltate(iii), MHCCo. A series of MHCCo complexes were synthesized and characterized by XRD and FT-IR techniques.

Synthesis of a Zirconium Complex of an ,-type --Butylcalix[4]arene and Its Application in Some Multicomponent Reactions.

The synthesis and characterization of a new octahedral Zr(IV) complex of oxygen-depleted ,-type calixarene ligand comprising two distal-functionalized pyrazole rings have been reported. The cone shape and structure of the prepared complex were confirmed univocally by single-crystal X-ray diffraction and NMR studies. The Zr metal lies at 2.

Synthesis and biological evaluation of imidazoline derivatives as potential CNS and CVS agents.

A series of substituted imidazoline derivatives were synthesized and characterized. Compounds were tested in-vivo for their antihypertensive, analgesic, antiaggressive, depressant, antidepressant, and ALD activities. The compounds 3a, 3c, 4c, 5a, and 6c showed cardiovascular as well as central nervous system activities and are potential candidate as drug among all fifteen compounds tested.

Green Synthesis of Copper Oxide Nanoparticles using Cucumis Sativus (Cucumber) Extracts and their Bio-Physical and Biochemical Characterization for Cosmetic and Dermatologic Applications.

Background & Objective: Nanoparticles are used in cosmetic and dermatologic products, due to better skin penetration properties. Incorporation of natural products exhibiting medicinal properties in nano-preparations could significantly improve the efficacy of these products and improve the quality of life without the side effects of synthetic formulations.

Methods: We here report the green synthesis of Copper Oxide nanoparticles, using Cucumber extract, and their detailed bio-physical and bio-chemical characterization.

Mode of action of tin-based anti-proliferative agents: Biological studies of organotin(IV) derivatives of fatty acids.

Some organotin(IV) carboxylates of the general formula RnSn(L)m [n=3, m=1, R=Me, Pr, Bu and Ph; n=2, m=2, R=Me, Bu and Oct; L=anion of lauric (HLA), stearic (HSA) and myristic acid (HMA)] have been synthesized and characterized by various spectroscopic studies. Tri- and diorganotin(IV) carboxylates adopt trigonal-bipyramidal and octahedral geometry around tin atom, respectively. They have been screened in vitro for anti-tumor activity against cancer cell lines of human origin, viz.

Tri- and diorganotin(IV) complexes of biologically important orotic acid: synthesis, spectroscopic studies, in vitro anti-cancer, DNA fragmentation, enzyme assays and in vivo anti-inflammatory activities.

Tri-and diorganotin(IV) orotates of general formula, R(n)Sn(H(2)Or)(m) [n = 3/2, m = 1/2, R = Me, n-Bu, n-Oct and Ph; H(2)Or(-) = monoanion of orotic acid (H(3)Or)] (n-Bu(2)Sn(HOr) as an exception) have been synthesized. On the basis of various spectroscopic studies it is revealed that R(3)Sn(H(2)Or) and R(2)Sn(H(2)Or)(2) exhibit distorted trigonal-bipyramidal and distorted octahedral geometry, respectively, and n-Bu(2)Sn(HOr) shows both five and six coordination geometry around tin. In vitro anti-cancer screening against MCF-7 (mammary), HEK-293 (kidney), PC-3 (prostate), HCT-15 (colon) and HepG-2 (liver) cancer cell lines suggest that the n-Oct(2)Sn(H(2)Or)(2) is the most active complex among all of the studied complexes.