Publications by authors named "Monika Tjota"
Article Synopsis
- Multicellular fungi have specialized cell-to-cell channels called septal pores, which allow communication and transport between cells.
- Researchers identified 17 proteins associated with septal pores (SPA proteins) that share similar physical properties but not primary sequences, indicating they may interact in an unstructured manner.
- Loss of SPA proteins leads to defects in septation and pore function, highlighting the septal pore's role as a complex hub for regulating intercellular connectivity.
The role of the cytoskeleton in protein trafficking is still being defined. Here, we describe a relationship between the small Ca(2+)-dependent membrane-binding protein Annexin B9 (AnxB9), apical β(Heavy)-spectrin (β(H)) and the multivesicular body (MVB) in Drosophila. AnxB9 binds to a subset of β(H) spliceoforms, and loss of AnxB9 results in an increase in basolateral β(H) and its appearance on cytoplasmic vesicles that overlap with the MVB markers Hrs, Vps16 and EPS15.
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