Click chemistry as a tool in biosensing systems for sensitive copper detection.

Copper detection for diagnostic purposes is an appealing field due to the important biological role copper plays as a trace metal. A convenient strategy for sensing copper is to utilize its catalytic ability. Therefore, this review summarizes approaches for copper determination by Cu-catalyzed azide/alkyne cycloaddition (CuAAC).

Proinsulin-specific T regulatory cells may control immune responses in type 1 diabetes: implications for adoptive therapy.

Objective: Here we looked for possible mechanisms regulating the progression of type 1 diabetes mellitus (T1DM). In this disease, autoaggressive T cells (T conventional cells, Tconvs) not properly controlled by T regulatory cells (Tregs) destroy pancreatic islets.

Research Design And Methods: We compared the T-cell compartment of patients with newly diagnosed T1DM (NDT1DM) with long-duration T1DM (LDT1DM) ones.