Publications by authors named "Monika Skutova"
Immunoablative therapy followed by autologous hematopoietic stem cell transplantation as the first-line disease-modifying therapy in patients with multiple sclerosis.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
March 2024
Introduction: Immunoablative therapy followed by autologous hematopoietic stem cell transplantation (AHSCT) is one of the possible disease-modifying therapies (DMTs) for patients with multiple sclerosis (MS). In this case series, we would like to present six patients with MS, who underwent AHSCT as the first-line DMT.
Case Reports: Six MS patients with a rapid progression of disability with or without relapses underwent AHSCT as the first-line DMT at the University Hospital Ostrava between 2018 and 2021.
Background: Only a few studies have been done focusing on the quality of life (QoL) of patients with multiple sclerosis (MS) as well as their family members. The aim of our research was to determine the factors that influence the QoL of MS patients in advanced stage of disease and their caregivers.
Methods: The sample of the cross-sectional study included 153 patients with MS and 74 caregivers.
Article Synopsis
- - The study explored the attitudes of progressive neurological disease (PND) patients and their families towards end-of-life care, involving 327 participants and using a specific questionnaire for data collection.
- - Significant differences were found, with families often wanting to prolong life at any cost, while patients preferred to have control over their end-of-life decisions.
- - Both groups agreed on the importance of patients expressing their treatment wishes in writing, highlighting the need for these preferences to be included in personalized care plans.
Background: Intrathecal IgM synthesis demonstrated either as cerebrospinal fluid (CSF)-restricted oligoclonal (o-) IgM bands or calculated using various formulas has been linked to more aggressive multiple sclerosis (MS) course. However, the proportion of MS patients showing intrathecal IgM synthesis varies largely between studies. We aimed to explore the relation between different formulas and results of o-IgM, and to assess the frequency of o-IgM bands in an unselected series of samples.
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