Retrospective Analysis of Treatment Pathways in Patients With BRAF-mutant Metastatic Colorectal Carcinoma - MORSE.

Background/aim: Metastatic colorectal cancer (mCRC) is a heterogeneous disease with distinct molecular subtypes. The BRAF-mutation found in approximately 8-12% of mCRC patients is associated with poor prognosis. Guideline recommendations for this population are mostly based on small cohorts due to lack of clinical data.

Does red noise increase or decrease extinction risk? Single extreme events versus series of unfavorable conditions.

Recent theoretical studies have shown contrasting effects of temporal correlation of environmental fluctuations (red noise) on the risk of population extinction. It is still debated whether and under which conditions red noise increases or decreases extinction risk compared with uncorrelated (white) noise. Here, we explain the opposing effects by introducing two features of red noise time series.

Extinction risk, coloured noise and the scaling of variance.

The impact of temporally correlated fluctuating environments (coloured noise) on the extinction risk of populations has become a main focus in theoretical population ecology. In this study we particularly focus on the extinction risk in strongly correlated environments. Here, we found that, in contrast to moderate auto-correlation, the extinction risk was highly dependent on the process of noise generation, in particular on the method of variance scaling.