Publications by authors named "Monika Paranjpe"
Article Synopsis
- The MAPK genes are important for gonadal differentiation in eutherian mammals, and this study investigates their role in marsupials, specifically the tammar wallaby.
- The researchers used a MAPK inhibitor, SB202190, to study its effects on gonads and found it reduced levels of key genes SOX9 and AMH in XY gonads.
- The study concludes that the MAPK pathway is involved in testis differentiation in marsupials, similar to its role in eutherian mammals.
Article Synopsis
- MAPKs play a role in gonadal differentiation in mice and humans, but their impact on other mammals, like the tammar wallaby, is less understood, prompting this investigation.
- The study involved RNA sequencing of tammar wallaby gonads from pre-birth to shortly after birth, and examined gene expression changes in male gonads when exposed to oestrogen.
- Results revealed that while MAP3K1 expression increased in male tammar gonads after oestrogen treatment, there was a decrease in male-determining genes and an increase in female markers, suggesting that MAP3K1 is responsive to hormonal changes during gonadal differentiation in this marsupial.
