Publications by authors named "Monika Mizerska"
The heart alters the rate and relative oxidation of fatty acids and glucose based on availability and energetic demand. Insulin plays a crucial role in this process diminishing fatty acid and increasing glucose oxidation when glucose availability increases. Loss of insulin sensitivity and metabolic flexibility can result in cardiovascular disease.
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- Acetyl-CoA carboxylase (ACC) is key for liver metabolism by creating malonyl-CoA, which aids in fat production and reduces fat burning.
- Inhibiting ACC led to increased supply of TCA cycle intermediates and enhanced gluconeogenesis, even during fasting, by activating key enzymes like CPT-1 and pyruvate carboxylase.
- This metabolic shift was linked to higher proteolysis and amino acid availability for glucose production, and was influenced by the activation of Nrf2, suggesting ACC's role goes beyond just fat metabolism.
Adiponectin is a secretory protein, primarily produced in adipocytes. However, low but detectable expression of adiponectin can be observed in cell types beyond adipocytes, particularly in kidney tubular cells, but its local renal role is unknown. We assessed the impact of renal adiponectin by utilizing male inducible kidney tubular cell-specific adiponectin overexpression or knockout mice.
View Article and Find Full Text PDFDe novo lipogenesis (DNL) is disrupted in a wide range of human disease. Thus, quantification of DNL may provide insight into mechanisms and guide interventions if it can be performed rapidly and noninvasively. DNL flux is commonly measured by H incorporation into fatty acids following deuterated water (HO) administration.
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