Publications by authors named "Monika Kula"

Article Synopsis
  • Claudins, specifically claudin-1 and claudin-4, are tight junction proteins involved in the progression of thyroid cancers and are potential therapeutic targets.
  • The study analyzed 162 thyroid samples from patients with various pathologies, finding distinct expression patterns: goiters had negative claudin-1 and mostly positive claudin-4, while papillary thyroid cancers and adenomas showed positive claudin-1 and claudin-4.
  • High expression levels of claudin-1 were linked to poorer overall survival rates in patients, highlighting its role as a prognostic factor and indicating a need for further trials to explore claudin targeting in clinical settings.
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Thyroid follicular nodules are quite common in the population, however only a small proportion is malignant. Thyroid cancer differs from adenoma by features of cellular atypia, angioinvasiveness and possibility of metastasis via blood vessels mainly in the lungs and bones. Pathomorphological examination of the postoperative material plays a significant role in the diagnosis of cystic thyroid lesions.

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One of the former definitions of "obligate anaerobiosis" was based on three main criteria: 1) it occurs in organisms, so-called obligate anaerobes, which live in environments without oxygen (O), 2) O-dependent (aerobic) respiration, and 3) antioxidant enzymes are absent in obligate anaerobes. In contrast, aerobes need O in order to grow and develop properly. Obligate (or strict) anaerobes belong to prokaryotic microorganisms from two domains, Bacteria and Archaea.

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The study was focused on the influence of salicylic acid (SA) on maize seeds germination and on some physiological and biochemical processes in maize plants growing in the hydroponic culture under copper (Cu) stress. A significant influence of SA pretreatment on the advanced induction of the maize seeds metabolic activity and the level of the endogenous SA in germinated seeds and developing roots have been stated. Although, the ability of maize seeds to uptake SA and accumulate it in the germinated roots was confirmed, the growth inhibition of Cu-stressed maize seedlings was not ameliorated by SA seeds pretreatment.

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