Pharmacokinetics of JNJ-73763989 and JNJ-56136379 (Bersacapavir) in Participants With Moderate Hepatic Impairment.

JNJ-73763989 is comprised of 2 short interfering RNAs (siRNAs), JNJ-73763976 and JNJ-73763924, that target hepatitis B virus (HBV) mRNAs for degradation, thereby inhibiting HBV replication. JNJ-56136379 is a capsid assembly modulator that inhibits HBV replication by inducing the formation of empty capsids (CAM-E). In 2 phase 1, open-label, non-randomized, single-center studies, the single-dose pharmacokinetics, safety, and tolerability of JNJ-73763989 or JNJ-56136379 were assessed in participants with moderate hepatic impairment (Child-Pugh Class B) versus participants with normal liver function.

Neutrophil to lymphocyte ratio (NLR) impact on the progression-free survival and overall survival of multiple myeloma patients treated with high-dose chemotherapy and autologous stem cell transplantation.

High-dose chemotherapy with autologous stem-cell transplantation (ASCT) remains the standard of care in multiple myeloma (MM) patients. This retrospective study aimed to assess the impact of neutrophil-to-lymphocyte ratio (NLR) and other complete blood count (CBC)-based predictors on PFS and OS of transplant-eligible MM patients. The CBC-based biomarkers were evaluated in a single-center cohort of 176 MM patients at three time points: at the diagnosis, the time of ASCT, and +100 d after ASCT.

Somatic comorbidity in Polish patients with epilepsy.

INTRODUCTION A wide spectrum of somatic and psychiatric disorders occurs frequently in patients with epilepsy, which adds to the burden of this disease. OBJECTIVES The aim of the study was to estimate the prevalence and risk factors of somatic comorbidities and analyze somatic comedication in adult patients with epilepsy. PATIENTS AND METHODS This study involved patients with epilepsy treated in university epilepsy clinic.

Psychiatric comedication in patients with epilepsy.

Psychiatric disorders are more common in patients with epilepsy than in the general population. The aims of the study were to assess the frequency and type of psychotropic drug usage in patients with epilepsy, to assess the risk factors for their use, and to assess their proconvulsive potential and the risk of interactions with antiepileptic drugs. This 20-month prospective study included patients treated at the university hospital outpatient clinic.

Geographical location and key sensitivity issues of post-industrial regions in Europe.

Primary objectives of our work were to spatially delineate post industrial areas of the EU-27 and indicate key environmental, social and economic sensitivity issues for these regions. The density of industrial sites within NUTS-x regions for EU-27 countries was assessed by using CORINE 2000 land cover layer. A development of postindustrial society in Europe represents a strong geographic diversity.

Cardiac arrest and its influence on the patient's psyche.

Cardiac arrest is a very important problem, because of its aetiology and consequences. It is defined as a sudden cessation of the pumping action of the heart, leading to death, which can be prevented if proper measures are taken immediately. A very important issue is the quality of life of patients after cardiac arrest and the presence of neurological and mental disorders.

Characteristics of depressive changes and anxiety in patients with essential hypertension.

Hypertension is among the world's most widespread diseases and one of the most frequent causes of mortality in the adult population. Clinical and experimental observations indicate the importance of psychic factors in the pathogenesis of hypertension. The aim of this study was to characterize depressive symptoms as well as to analyze anxiety level in patients with essential hypertension.

Psychosomatic aspects of arterial hypertension in women.

Arterial hypertension is one of the most widespread diseases in the world, both in women and men. In Poland, about 45% of the adult population suffers from arterial hypertension--it afflicts 45% of men and 36-38% of women. Arterial hypertension is a set of regulatory disorders of a complicated, multifactor etiology encompassing genetic conditions, the influence of the environment and some individual factors.

A brief study about the dignity of man.

The present paper is devoted to the problem of human dignity, exploring its philosophical, psychological and religious aspects. This issue is so important in all spheres of everyday life and yet we often forget about it when we deal with our mundane problems. The paper also analyzes human dignity with regard to medicine, especially the doctor-patient relationship.