Publications by authors named "Monika Hexel"
Int J Cancer
September 2019
Article Synopsis
- Idelalisib enhances the generation of chimeric antigen receptor T (CART) cells by increasing the proportion of less-differentiated T cells, which improves their growth and longevity in patients.
- Idelalisib treatment leads to a decrease in exhaustion markers and alters CD4:CD8 ratios in CART cells from chronic lymphocytic leukemia (CLL) patients, making them more similar to those from healthy donors.
- In vivo tests in a mouse model show that idelalisib-treated CART cells have effective anti-tumor activity, suggesting that further research on idelalisib-based CART cell protocols could lead to better cancer treatments.
