Atrial natriuretic peptide serum concentration decreases in donors undergoing discontinuous plasmapheresis involving a large extracorporeal blood volume.

Background: In donor plasmapheresis, circulatory reactions occur at a similar frequency as in whole-blood donation although the large extracorporeal blood volume (ECV) occurring during discontinuous plasmapheresis might predispose donors to hypovolemic reactions. The regulatory mechanisms compensating for this intradonation blood volume (BV) deficit are not well understood. It was the aim of this study to delineate whether atrial natriuretic peptide (ANP) is involved in the BV regulation of plasmapheresis donors.

Blood volume regulation in donors undergoing intermittent-flow plasmapheresis involving a high extracorporeal blood volume.

Background: Intermittent-flow plasmapheresis (IFP) often involves a large extracorporeal blood volume (ECV) of donors during donation. Depending on equipment and donor characteristics, ECV can exceed 20 percent of a donor's blood volume (BV). It was the aim of this study to delineate mechanisms of BV regulation associated with these volume shifts.