Publications by authors named "Monika Gelker"
Endophilins-A are conserved endocytic adaptors with membrane curvature-sensing and -inducing properties. We show here that, independently of their role in endocytosis, endophilin-A1 and endophilin-A2 regulate exocytosis of neurosecretory vesicles. The number and distribution of neurosecretory vesicles were not changed in chromaffin cells lacking endophilin-A, yet fast capacitance and amperometry measurements revealed reduced exocytosis, smaller vesicle pools and altered fusion kinetics.
View Article and Find Full Text PDFPlasma Permeabilization of Human Excised Full-Thickness Skin by µs- and ns-pulsed DBD.
Skin Pharmacol Physiol
March 2021
Introduction: Cold atmospheric plasma (CAP) is gaining increasing importance as a medical or cosmetic treatment for various indications. The technology is best suited to the treatment of surfaces such as the skin and is already used in wound care and, in exemplary case studies, the reduction of superficial tumors. Several plasma sources have been reported to affect the skin barrier function and potentially enable drug delivery across or into plasma-treated skin.
View Article and Find Full Text PDFArticle Synopsis
- Recent research into cold atmospheric plasma suggests its potential in medical applications, particularly for improving drug delivery through skin by evaluating different dielectric barrier discharges (DBDs).
- Various imaging techniques and electrical resistance measurements were utilized to assess how effectively different types of DBDs could create pores in the outer layer of human skin (stratum corneum).
- The study found that μs-pulsed DBDs were effective at forming pores, while ns-pulsed DBDs were gentler and less damaging, emphasizing the need for tailored plasma characteristics for specific treatment purposes.