Rheological properties of pharmaceutical substrates produced with Celugel.

Background: Hydrogels, containing a large amount of water and exhibiting high biocompatibility, can improve the rheological properties of formulations and adhere well to the application site. In Poland, only 1 hydrogel substrate is currently approved for pharmaceutical compounding: Celugel, based on hydroxyethyl cellulose (HEC).

Objectives: The aim of this study was to investigate how the variation in the raw material composition of Celugel-based hydrogels affects their osmotic pressure values and selected rheological properties.

The Influence of Initiators, Particle Size and Composition on the Electrokinetic Potential of N-(Isopropyl)acrylamide Derivatives.

The aim of this study was to characterize and compare the zeta potential of particles sensitive to external thermal stimuli. Poly N-(isopropyl) acrylamide (PNIPA) was selected as the thermosensitive polymer with a volume phase transition temperature (VPTT) between 32 and 33 °C. The hydrodynamic diameter (D) of the nanoparticles was measured by dynamic light scattering.

The influence of selected polymers on the surface tension of solutions developed for the preparation of eye drops.

Background: Many substances are used to increase the viscosity of eye drops and reduce their surface tension. Their function is to prolong the persistence of the product on the surface of the eyeball and to increase the bioavailability of the pharmacologically active ingredient.

Objectives: To investigate the surface tension of substances added to the eye drops, with the main aim of modulating properties of the preparation.

Effect of Selected Comonomers on the Transition Temperature of Thermosensitive NIPA Derivatives Synthesized with an Anionic Initiator.

The present study evaluates the effect of the cationic initiator on the hydrodynamic diameter of copolymers of -isopropylacrylamide nanogels synthesized via a surfactant-free precipitation polymerization at 70 °C in the presence of the cationic initiator 2,2'-azobis[2- methylpropionamidine] dihydrochloride. Three types of polymeric nanoparticles were synthesized using '-methylenebisacrylamide as a crosslinker. The first batch was used as a reference.

Influence of Hydrophilic Co-Monomer on the Drug Release from Hydrogels with Thermosensitive -(isopropyl)acrylamide Derivatives.

Polymers sensitive to external stimuli are intensively studied. They are used for preparation of controlled drug delivery systems for variety of active pharmaceutical ingredients. Poly--isopropyl acrylamide is a temperature sensitive polymer, and its properties have been used to obtain a series of thermally sensitive polymeric structures.

INFLUENCE OF LIPOPHILIC AND HYDROPHILIC CO-MONOMERS ON THE HYDRODYNAMIC DIAMETER OF THERMOSENSITIVE NIPA DERIVATIVES FOR THERMALLY CONTROLLED DRUG DELIVERY.

For modem drug delivery, new drug carriers sensitive to various factors and with size in the range of micro- and nanometers are required. The aim of this work was to evaluate the influence of hydrophilic and hydrophobic co-monomers on the hydrodynamic diameter of three co-polymers of N-isopropylacrylamide (NIPA) nanogels synthesized at 70*C in the presence of potassium persulfate (KPS) as the initiator and N.N'-methylene bis-acrylamide (MBA) as the cross-linker.

Application of Polymerization Activator in the Course of Synthesis of N-Isopropylacrylamide Derivatives for Thermally Triggered Release of Naproxen Sodium.

Poly--isopropylacrylamide (polyNIPA) is an extensively studied polymer in the field of controlled drug delivery. PolyNIPA contains carbonyl and amide groups along a hydrophobic chain. In an aqueous environment, crosslinked polyNIPA forms a gel characterized by a reversible volume phase transition temperature (VPTT), in response to changes in the external environment excited by the temperature factor.

Synthesis and Formulation of Thermosensitive Drug Carrier for Temperature Triggered Delivery of Naproxen Sodium.

Nanospheres and microspheres are known as a multipurpose compounds and are used in various branches of science. Recent controlled delivery systems for drugs are also based on poly-micro and nanospheres. In our study we describe an investigation of the influence of thermosensitive polymer -isopropylacrylamide (NIPA) on the release of the drug naproxen sodium (NS) with a hydrogel hydroxypropyl methylcellulose (HPMC) base.

[Effect of the medium composition on the properties of gels based on sodium carboxymethylcellulose].

Background: Sodium carboxymethylcellulose is a hydrogel substrate used in the Drug Formulation Technology to produce skin dressings, dental gels and the ophthalmic drugs.

Objectives: To study the hydrophilic medium composition based on the sodium carboxymethylcellulose and excipients on the properties of hydrogels with 1% hydrocortisone.

Material And Methods: Sodium carboxymethylcellulose, hydrocortisone, Tween 20, Ethanol 760 g/l, propylene glycol-1,2, N,N-dimethylacetamide, aqua purificata P Ph 9th.