Higher spermidine intake is linked to lower mortality: a prospective population-based study.

Background: Spermidine administration is linked to increased survival in several animal models.

Objective: The aim of this study was to test the potential association between spermidine content in diet and mortality in humans.

Design: This prospective community-based cohort study included 829 participants aged 45-84 y, 49.

Association of polymorphisms in the endocannabinoid system genes with myocardial infarction and plasma cholesterol levels.

Aims: The aim of this study was to investigate the relationship between selected symptoms of chronic heart failure (myocardial infarction, plasma cholesterol level) and single nucleotide polymorphisms (SNPs) in the FAAH and CNR1 genes.

Methods: A case - control study involving 155 patients with chronic heart failure and 169 age- and sex-matched healthy subjects. We detected SNPs 385 C/A (rs324420) in the FAAH and 1359 G/A (rs1049353) in the CNR1 genes using the polymerase chain reaction and restriction analysis.