A Novel Extra Tree Ensemble Optimized DL Framework (ETEODL) for Early Detection of Diabetes.

Diabetes has been recognized as a global medical problem for more than half a century. Patients with diabetes can benefit from the Internet of Things (IoT) devices such as continuous glucose monitoring (CGM), intelligent pens, and similar devices. Smart devices generate continuous data streams that must be processed in real-time to benefit the users.

Targeting cholesterol synthesis increases chemoimmuno-sensitivity in chronic lymphocytic leukemia cells.

Background: Cholesterol plays an important role in cancer development, drug resistance and chemoimmuno-sensitivity. Statins, cholesterol lowering drugs, can induce apoptosis, but also negatively interfere with CD-20 and rituximab-mediated activity. Our goal is to identify the alternative targets that could reduce cholesterol levels but do not interfere with CD-20 in chemo immunotherapy of chronic lymphocytic leukemia (CLL).

Combined small-cell lung carcinoma: An institutional experience.

Background: The purpose of this study is to determine prognostic factors and survival in patients who present with combined small-cell lung cancer (SCLC).

Methods: A retrospective review of combined SCLC histology in patients treated between1995-2010 was undertaken. Demographics, diagnostic information, disease characteristics, treatment modality, and survival were captured.

Postoperative bleeding in an elderly patient from acquired factor V inhibitor: rapid response to immunosuppressive therapy.

Acquired factor V inhibitor is a rare but potentially life-threatening hemorrhagic disorder caused by the development of autoantibodies directed against coagulation factor V. The management of acute bleeding and inhibitor eradication is the mainstay of the treatment. The authors report a case of a 79-year-old man who underwent right hip arthroplasty and postoperatively, when on Coumadin for deep venous thrombosis prophylaxis, developed bleeding from the surgical site with a hematoma and abnormal coagulation parameters.