Publications by authors named "Monica Velasco"
Article Synopsis
- The study investigates how B cell populations and their receptors evolve in the intestines of humans, particularly after intestinal transplantation, using biopsies for observation.
- Researchers employed advanced techniques like polychromatic flow cytometry and B cell receptor sequencing to differentiate between donor and recipient B cells and assess their development in the transplanted intestines.
- Findings reveal that recipient B cells, including memory B cells, rapidly populate the transplanted intestines mainly in infants, and their B cell receptors evolve differently in the graft compared to circulation, with notable clonal mixing remaining years after the transplant.
Article Synopsis
- * Researchers analyzed blood, lymphoid, and gut samples from 16 ITx patients using flow cytometry and next-generation sequencing to explore the origins and specificities of TRMs.
- * Findings showed that recipient TRM repertoires in transplanted ileum are influenced by donor age and T cell macrochimerism, with a notable overlap of T cell receptor sequences between gut and blood, suggesting ongoing interactions for years post-transplant.
Article Synopsis
- The study examines how B cell populations and their receptors (BCRs) are formed and maintained in the intestine after intestinal transplantation (ITx).
- Researchers used advanced techniques to analyze B cells from both donors and recipients, revealing that recipient B cells, including memory B cells, quickly established themselves in the transplant's mucosa, especially in infants.
- Despite ongoing changes in B cell populations post-transplant, there is no evidence of a stable B cell repertoire being formed in the gut tissue, even years after the procedure.
We present a case of a pediatric liver transplant recipient diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection four days after receiving a living donor liver allograft from her mother. The recipient was a 6-month-old with end-stage liver disease due to biliary atresia and failed Kasai. The infant had an uncomplicated implantation, excellent graft function and down-trending liver enzymes until developing fevers, diarrhea, and moderate respiratory distress requiring non-invasive respiratory support.
View Article and Find Full Text PDFObjective: To compare efficacy, safety/side effects and acceptability of buccal versus sublingual administration of a misoprostol-only regimen commonly used for early medical abortion.
Study Design: We conducted a randomized trial at six clinics in two Latin American countries. We randomized women seeking early abortion to buccal or sublingual administration of three doses of misoprostol 800 mcg repeated every 3 h.
Nutritional Challenges in Patients After Intestinal Autotransplantation and Ex Vivo Surgery.
JPEN J Parenter Enteral Nutr
February 2019
Background: Intestinal autotransplantation (IATx) and ex vivo resection is a novel surgical strategy to treat patients with unresectable abdominal neoplasms involving the mesenteric root. Nutritional challenges after IATx and ex vivo surgery have not been well described.
Methods: Eleven patients, aged 7-68 years (median, 49 years) underwent IATx and ex vivo resection at our center from 2009 to 2016.
Ganglioneuromas are slow growing, clinically silent benign tumors for which surgery is considered to be the standard treatment. However, surgical excision in cases where surrounding structures are involved can be challenging. The present study reports a novel technique of excision for the management of a retroperitoneal ganglioneuroma in a 21-year old patient, that appeared to be inoperable using standard surgical resection.
View Article and Find Full Text PDFBy preserving part of the native liver, auxiliary partial orthotopic liver transplantation (APOLT) provides the advantage of potential immunosuppression (ISP) withdrawal if the native liver recovers but has had limited acceptance, especially in the United States, due to technical complications and low rates of native liver regeneration. No previous study has evaluated APOLT specifically for preadolescent children with fulminant hepatic failure (FHF). This population might benefit especially based on greater capacity for liver regeneration.
View Article and Find Full Text PDFObjective: To describe a single-center experience of pediatric intestinal transplantation (Itx) and to provide an overview of the children who underwent this procedure along with their outcomes.
Summary Background Data: Pediatric Itx presents multiple challenges because of the very young ages at which patients require transplantation and their higher susceptibility to infectious complications.
Methods: We have performed 141 Itx in 123 children with a median age of 1.