Publications by authors named "Monica Valencia-Gattas"
Page 1 of 1
Synopsis of recent research by authors named "Monica Valencia-Gattas"
- Recent research by Monica Valencia-Gattas primarily focuses on the effects of oxidative stress and the respiratory epithelial response to cigarette smoke, highlighting the involvement of various cellular mechanisms and ion channels in maintaining airway epithelial integrity and function
- Key findings indicate that proton channel blockers can inhibit Duox activity independent of Hv1, and that exposure to cigarette smoke reduces ciliated airway epithelial cells, which are crucial for respiratory defense mechanisms, emphasizing the therapeutic potential of EGFR inhibitors like Gefitinib in mitigating these effects
- Additional studies reveal that hyaluronan and layilin contribute to impaired barrier function in the airway epithelium following smoke exposure, while the regulation of oxidative host defense responses involves interactions between inflammatory stimuli and epithelial oxidative stress pathways
