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Publications by authors named "Monica Tassa"

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qPCR detection of Mycobacterium leprae in biopsies and slit skin smear of different leprosy clinical forms.
Michelle de Campos Soriani Azevedo Natália Mortari Ramuno Luciana Raquel Vincenzi Fachin Mônica Tassa Patrícia Sammarco Rosa

Braz J Infect Dis

August 2017

Article Synopsis
  • Leprosy, caused by Mycobacterium leprae, is a chronic infection mainly impacting the skin and nerves, with diagnosis traditionally based on clinical evaluation and supported by histopathological analysis.
  • A study analyzed 126 skin biopsies and 25 slit skin smears using quantitative PCR (qPCR) and routine bacilloscopy to compare diagnostic effectiveness, finding qPCR to be highly sensitive and specific.
  • The qPCR technique demonstrated 84.9% sensitivity in skin biopsies and 100% specificity, suggesting it is a reliable complementary diagnostic tool for leprosy across all clinical forms.
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