Publications by authors named "Monica T L Villanueva"
Novel active Trp- and Arg-rich antimicrobial peptides with high solubility and low red blood cell toxicity designed using machine learning tools.
Bridget A B Henson Fucong Li José Ausencio Álvarez-Huerta Poornima G Wedamulla Arianna Valdes Palacios Monica T L Villanueva
Int J Antimicrob Agents
December 2024
Article Synopsis
- * Machine learning techniques were used to identify and rank potential non-hemolytic AMPs from two libraries of peptide sequences, leading to the synthesis and testing of 220 peptides against Methicillin-resistant Staphylococcus aureus (MRSA).
- * Six promising AMPs were further analyzed for their effectiveness against various bacteria and cancer cell lines, revealing a successful strategy for creating effective and safe antimicrobial agents, while also setting a foundation for future research and machine learning applications in peptide design.