Publications by authors named "Monica Silvestri"
Cancer remains a major challenge in medicine, prompting exploration of innovative therapies. Recent studies suggest that exercise-derived extracellular vesicles (EVs) may offer potential anti-cancer benefits. These small, membrane-bound particles, including exosomes, carry bioactive molecules such as proteins and RNA that mediate intercellular communication.
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- Breast cancer (BC) is a major global health issue for women, and studies show that physical activity (PA) can significantly improve quality of life, recovery, and survival rates in BC patients.
- PA affects DNA methylation, potentially reversing abnormal patterns linked to cancer and other diseases, and this review highlights how PA influences both global and gene-specific DNA methylation in BC patients.
- The analysis indicates that PA can elevate global DNA methylation in tumors and affects various genes associated with important biological processes, underscoring its potential to restore normal cell function and improve recovery and survival outcomes for BC patients.
Article Synopsis
- - Biological age is a more accurate reflection of health than chronological age, and a study shows that a 16-week online physical activity program can significantly reduce biological age in breast cancer survivors post-surgery.
- - Although telomere length remained unchanged, the ELOVL2 epigenetic clock indicated that participants in the physical activity group experienced a reduction in biological age, linked to improvements in cardiovascular fitness and strength.
- - The study suggests that incorporating physical activity can support better recovery for breast cancer patients and highlights the potential of epigenetic clocks as a tool to assess health status and identify at-risk individuals.
Background: Workplace violence (WPV) against health professionals is a global problem with an increasing incidence. The aims of this study were as follows: 1) to examine the frequency and characteristics of WPV in different settings and professionals of a general hospital and 2) to identify the clinical and organizational factors related to this phenomenon.
Methods: The study was cross-sectional.