Publications by authors named "Monica Silveira Wagner"
Long-term resistance to 5-fluorouracil promotes epithelial-mesenchymal transition, apoptosis evasion, autophagy, and reduced proliferation rate in colon cancer cells.
Eur J Pharmacol
October 2022
Article Synopsis
- The study focused on 5-fluorouracil (5FU), a common treatment for colorectal cancer (CRC), emphasizing the development of drug resistance in cancer cells.
- Researchers created a long-term 5FU-resistant model (HCT-116 5FUR) and found that these cells showed increased resistance not only to 5FU but also to other drugs, like oxaliplatin, revealing cross-resistance mechanisms.
- The resistant cells exhibited metabolic changes, increased migration and invasion capabilities, and activation of processes like autophagy, suggesting a complex interplay of cellular events that contribute to treatment failure in CRC patients.
SCRIB is a scaffold protein containing leucine-rich repeats (LRR) and PSD-95/Dlg-A/ZO-1 domains (PDZ) that localizes at the basolateral membranes of polarized epithelial cells. Deregulation of its expression or localization leads to epithelial defects and tumorigenesis in part as a consequence of its repressive role on several signaling pathways including AKT, ERK, and HIPPO. In the present work, a proteomic approach is used to characterize the protein complexes associated to SCRIB and its paralogue LANO.
View Article and Find Full Text PDFBackground: Triple-negative breast cancers (TNBC) are poor-prognosis tumours candidate to chemotherapy as only systemic treatment. We previously found that PRICKLE1, a prometastatic protein involved in planar cell polarity, is upregulated in TNBC. We investigated the protein complex associated with PRICKLE1 in TNBC to identify proteins possibly involved in metastatic dissemination, which might provide new prognostic and/or therapeutic targets.
View Article and Find Full Text PDFTriple-negative breast cancer represents about 15% of all cases of breast cancer, and still represents a therapeutic challenge. 3'-Azido-3'-deoxythymidine (AZT) is a nucleoside reverse transcriptase inhibitor with antitumor activity. Chalcogenides compounds, such as selenium, are very important intermediates applied in organic synthesis.
View Article and Find Full Text PDFMost human populations are undergoing a demographic transition regarding their age structure. This transition is reflected in chronic non-communicable diseases featuring among the main contributors to burden of disease. Considering that the aging process is a major risk factor for such conditions, understanding the mechanisms underlying aging and age-related diseases is critical to develop strategies to impact human health at population and/or individual-levels.
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