Publications by authors named "Monica Sherin"
Article Synopsis
- The medial temporal lobe is crucial for episodic memory and is affected differently by aging and Alzheimer's disease, with each condition showing distinct patterns of vulnerability.
- In preclinical Alzheimer's, there's an increase in functional connectivity in the medial temporal lobe, which declines as the disease progresses into its symptomatic phase.
- Normal aging leads to decreased connectivity in both the Anterior-Temporal and Posterior-Medial networks, indicating a decline in memory-related brain functions across age.
Functional disruption of the medial temporal lobe-dependent networks is thought to underlie episodic memory deficits in aging and Alzheimer's disease. Previous studies revealed that the anterior medial temporal lobe is more vulnerable to pathological and neurodegenerative processes in Alzheimer's disease. In contrast, cognitive and structural imaging literature indicates posterior, as opposed to anterior, medial temporal lobe vulnerability in normal aging.
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