Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Pteridine Reductase in Support of Early-Stage Drug Discovery.

Pteridine reductase-1 (PTR1) is a promising drug target for the treatment of trypanosomiasis. We investigated the potential of a previously identified class of thiadiazole inhibitors of PTR1 for activity against (). We solved crystal structures of several PTR1-inhibitor complexes to guide the structure-based design of new thiadiazole derivatives.