Publications by authors named "Monica Pastorino"
Article Synopsis
- * Researchers identified PANDAR, a long non-coding RNA (lncRNA), as significantly up-regulated in APCs of individuals with obesity, particularly those transitioning from normal glucose tolerance to impaired glucose tolerance or T2D.
- * Silencing PANDAR in senescent APCs appears to reverse senescence and enable cell cycle re-entry, suggesting that targeting PANDAR may offer a new approach to prevent or delay the progression toward T2D in obese patients.
Background: Cardiovascular diseases (CVD) affect over half a billion people worldwide and are the leading cause of global deaths. In particular, due to population aging and worldwide spreading of risk factors, the prevalence of heart failure (HF) is also increasing. HF accounts for approximately 36% of all CVD-related deaths and stands as the foremost cause of hospitalization.
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