circRNA from Gene Changes in Alzheimer's Disease Human Brain.

Alzheimer's disease (AD) is the most common cause of age-related dementia. Amyloid precursor protein () is the precursor of Aβ peptides, and its role in AD has been widely investigated. Recently, it has been reported that a circular RNA (circRNA) originated from gene can serve as a template for Aβ synthesis, postulating it as an alternative pathway for the Aβ biogenesis.