Publications by authors named "Monica M Nader"
Article Synopsis
- The angiotensin type 2 receptor (ATR) plays a crucial but still unclear role in lung health, particularly in alveolar fibroblasts, contrasting with the angiotensin type 1 receptor (ATR) that is found mainly in lung pericytes.
- Disruption of ATR leads to increased oxidative stress and worsened lung permeability, especially during Hyperoxic Acute Lung Injury (HALI), with aging mice exhibiting more severe lung damage and higher mortality when lacking ATR.
- Research indicates that using Losartan to block ATR may not offer protective benefits in ATR-deficient mice, while the ATR agonist Compound 21 (C21) shows promise in reversing lung damage, suggesting a shift in treatment strategies to enhance ATR function instead of blocking it
While physical frailty has been recognized as a clinical entity for some time, the concept of cognitive frailty (CF) is now gaining increasing attention in the geriatrics research community. CF refers to the co-occurrence of physical frailty and cognitive impairment in older adults, which has been suggested as a potential precursor to both dementia and adverse physical outcomes. However, this condition represents a challenge for researchers and clinicians, as there remains a lack of consensus regarding the definition and diagnostic criteria for CF, which has limited its utility.
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