Synopsis of recent research by authors named "Monica Luengo"
- Monica Luengo's research focuses on the synthesis and pharmacological evaluation of novel compounds targeting selective sigma receptors, particularly σ1 receptors.
- In her 2013 publication, she presents a new series of hexahydro-2H-pyrano[3,2-c]quinoline derivatives, which are identified as potent σ1R ligands, distinctively lacking the typical highly basic amino group found in other ligands.
- The findings reveal that among the created diastereoisomers, only one demonstrated significant activity and selectivity towards σ1R over σ2R, aligning well with known σ1R pharmacophore structures.
