DNA Vaccine Treatment in Dogs Experimentally Infected with .

Chagas disease is a chronic and potentially lethal disorder caused by the parasite , and an effective treatment has not been developed for chronic Chagas disease. The objective of this study was to determine the effectiveness of a therapeutic DNA vaccine containing genes in dogs with experimentally induced Chagas disease through clinical, pathological, and immunological analyses. Infection of Beagle dogs with the H8 strain was performed intraperitoneally with 3500 metacyclic trypomastigotes/kg body weight.