Aluminium Binding to Modified Amyloid-β Peptides: Implications for Alzheimer's Disease.

Aluminium (Al) is clearly neurotoxic and considerable evidence exists that Al may play a role in the aetiology or pathogenesis of Alzheimer's disease (AD). Nevertheless, the link between AD pathology and Al is still open to debate. Therefore, we investigated here the interaction of aluminium ions with two Aβ peptide fragments and their analogues.

Stoichiometry of Heavy Metal Binding to Peptides Involved in Alzheimer's Disease: Mass Spectrometric Evidence.

Mass spectrometry is a powerful analytical technique becoming increasingly important in different biomedical research area. Mass spectrometric based methods were developed and applied to detect and identify multiple metal ion complexes of peptides and proteins with high sensitivity and high mass accuracy. Aggregation of amyloid-β (Aβ) peptides is one of the main pathological features of Alzheimer's disease (AD), and some metal ions seem to play a key role in AD pathogenesis.

Synthetic quinolone signal analogues inhibiting the virulence factor elastase of Pseudomonas aeruginosa.

We explore the chemical space of Pseudomonas quinolone signal analogs as privileged structures and report the discovery of a thioquinolone as a potent inhibitor of the important virulence factor elastase of the human pathogen Pseudomonas aeruginosa. We provide evidence that the derivative binds to the active site zinc of elastase and additionally acts as a fluorescent zinc sensor.