Comparative Risk of Anaphylactic Reactions Associated With Intravenous Iron Products.

Importance: All intravenous (IV) iron products are associated with anaphylaxis, but the comparative safety of each product has not been well established.

Objective: To compare the risk of anaphylaxis among marketed IV iron products.

Design, Setting, And Participants: Retrospective new user cohort study of IV iron recipients (n = 688,183) enrolled in the US fee-for-service Medicare program from January 2003 to December 2013.