Effect of glycine on the immune response of the experimentally diabetic rats.

Background: Hyperglycemia induces protein glycation, disturbing its function, additionally, the glycated products (AGEs) induce by themselves proinflammatory cytokine release that are responsible for insulin resistance. Glycine has been successfully used in diabetic patients to competitively reduce hemoglobin glycation.

Objectives: To assess hyperglycemia impact on the immune response and to evaluate if it is possible to reverse it by means of glycine administration.