Nasal immunization with H7 flagellin protects mice against hemolytic uremic syndrome secondary to O157:H7 gastrointestinal infection.

Introduction: Shiga-toxin (Stx) producing (STEC) O157:H7 is the most frequent serotype associated with hemolytic uremic syndrome (HUS) after gastrointestinal infections. Protection against HUS secondary to STEC infections has been experimentally assayed through the generation of different vaccine formulations. With focus on patients, the strategies have been mainly oriented to inhibit production of Stx or its neutralization.

Make It Simple: (SR-A1+TLR7) Macrophage Targeted NANOarchaeosomes.

Hyperhalophilic archaebacteria exclusively produce sn2,3 diphytanylglycerol diether archaeolipids, unique structures absent in bacteria and eukaryotes. Nanovesicles made of archaeolipids known as nanoarchaeosomes (nanoARC), possess highly stable bilayers, some of them displaying specific targeting ability. Here we hypothesize that nanoARC made from archaebacteria, may constitute efficient carriers for the TLR7 agonist imiquimod (IMQ).

The impact of extracellular acidosis on dendritic cell function.

Dendritic cells (DCs) are the most efficient antigen-presenting cells. They are activated in the periphery by conserved pathogen molecules and by inflammatory mediators produced by a variety of cell types in response to danger signals. It is widely appreciated that inflammatory responses in peripheral tissues are usually associated with the development of acidic microenvironments.