Impact of type 2 diabetes mellitus on mortality and recurrence of clostridioides difficile infection.

Background: Clostridioides difficile infection (CDI) is the leading cause of healthcare-associated diarrhea. The infection is associated with a high mortality rate and risk of recurrence. We assessed risk factors for death or recurrent CDI (CDI) in patients with diabetes mellitus (DM).

First Report of an Extensively Drug-Resistant ST23 of Capsular Serotype K1 Co-Producing CTX-M-15, OXA-48 and ArmA in Spain.

An extensively drug-resistant (XDR) isolate MS3802 from a tracheostomy exudate was whole-genome sequenced using MiSeq and Oxford Nanopore MinION platforms in order to identify the antimicrobial resistance and virulence determinates and their genomic context. Isolate MS3802 belonged to the clone ST23 and presented a capsular serotype K1, associated with hypervirulent (hvKp) isolates. The isolate harboured a chromosomally encoded gene and contained a large IncHI1B hybrid virulence/resistance plasmid carrying another copy of the and the virulence factors and The carbapenemase gene was found in a Tn-like transposon and the 16S rRNA methylase gen located in the vicinity of other antibiotic-resistant genes on an IncM2 plasmid.

[Epidemiology of Clostridium difficile-associated disease (CDAD) in Salamanca].

Introduction: Clostridium difficile infection is considered a major cause of nosocomial diarrhoea in developed countries and is increasingly becoming more important as an etiologic agent of community diarrhoea, also in patients without risk factors.

Method: Beginning in May 2011, the aim of our study is to know the characteristics of patients suffering from C. difficile Associated Disease in Salamanca University Hospital, collecting their data in a survey conducted for this purpose.