Total Synthesis and Absolute Configuration Determination of the α-Glycosidase Inhibitor (3,4)-6-Acetyl-3-hydroxy-2,2-dimethylchroman-4-yl ()-2-Methylbut-2-enoate from .

Herein, we report the first total synthesis of α-glycosidase inhibitor (3, 4)-6-acetyl-3-hydroxy-2,2-dimethylchroman-4-yl ()-2-methylbut-2-enoate as well as its enantiomer. Our synthesis confirms the chromane structure separately proposed by Navarro-Vazquez and Mata, on the basis of DFT computations. Furthermore, our synthesis allowed us to determine the absolute configuration of the natural compound as (3, 4) and not (3, 4).

Protective Effects of Rifampicin and Its Analog Rifampicin Quinone in a Mouse Model of Obesity-Induced Type 2 Diabetes.

Advanced glycation end-products (AGEs) form when glucose reacts non-enzymatically with proteins, leading to abnormal protein function, oxidative stress, and inflammation. AGEs are associated with aging and age-related diseases; their formation is aggravated during diabetes. Therefore, drugs preventing AGE formation can potentially treat diabetic complications, positively affecting health.