A New Biomechanical Deformation Response Parameter: Change in Central Corneal Thickness During Air Puff Induced Corneal Deformation.

Purpose: To investigate the percent change in central corneal thickness (%ΔCCT) during air-puff-induced deformation as an indicator of corneal biomechanical response.

Methods: Forty human eyes from forty donors were imaged using the CorVis ST at experimentally controlled intraocular pressure (IOP) of 10, 20, 30, and 40 mmHg, followed by uniaxial strip testing to calculate tensile modulus. The CorVis ST research software tracked the anterior and posterior cornea edges and determined the dynamic corneal response (DCR) parameters.

Changes in Central Corneal Thickness With Air-Puff-Induced Corneal Deformation Using a Method to Correct Scheimpflug and Refractive Distortion.

Purpose: To establish a method to determine central corneal thickness (CCT) and anterior chamber depth (ACD) of an air-puff-deformed cornea at the highest concavity (HC) state.

Methods: The Fink method for refractive correction of Scheimpflug images of a convex pre-deformed (PRE) cornea was implemented for 155 eyes of 155 participants imaged with the Corvis ST (Oculus Optikgeräte GmbH). This method was subsequently modified for the HC state of deformation.

Characteristics of the cerebrospinal fluid pressure waveform and craniospinal compliance in idiopathic intracranial hypertension subjects.

Background: Idiopathic intracranial hypertension (IIH) is a condition of abnormally high intracranial pressure with an unknown etiology. The objective of this study is to characterize craniospinal compliance and measure the cerebrospinal fluid (CSF) pressure waveform as CSF is passively drained during a diagnostic and therapeutic lumbar puncture (LP) in IIH.

Methods: Eighteen subjects who met the Modified Dandy Criteria, including papilledema and visual field loss, received an ultrasound guided LP where CSF pressure (CSFP) was recorded at each increment of CSF removal.