A single-center case study series assessing the effect of selumetinib use in patients with neurofibromatosis-related plexiform neurofibromas.

Background: Neurofibromatosis type 1 (NF1) is a common genetic disorder of phenotypic variability with age-dependent penetrance. This study describes the diagnosis, clinical characterization, management, and outcomes of a large patient cohort with plexiform neurofibroma (PN) treated with selumetinib in a real-world clinical setting.

Methods: This single-center observational study consecutively enrolled patients with NF1-PN treated with selumetinib from April 2018 to 2023.

Dynamic magnetic resonance imaging of the female pelvic floor-a pictorial review.

Pelvic floor dysfunctions represent a range of functional disorders that frequently occur in adult women, carrying a significant burden on the quality of life, and its incidence tends to increase attending to the expected aging of the population. Pelvic floor dysfunctions can manifest as incontinence, constipation, and prolapsed pelvic organs. Since pelvic floor weakness is frequently generalized and clinically underdiagnosed, imaging evaluation is of major importance, especially prior to surgical correction.

Relation between respiratory muscle strength with respiratory complication on the heart surgery.

Objective: To check the respiratory muscle strength in cardiac surgery and the relationship with the postoperative pulmonary complications.

Methods: Sixty-tree adult's patients undergoing elective cardiac surgery were enrolled in this study. In the day of the surgery all patients did the respiratory muscle strength test.