Publications by authors named "Monica Colpini Avila"
Sex-specific differences on caffeine consumption and chronic stress-induced anxiety-like behavior and DNA breaks in the hippocampus.
Cristie Grazziotin Noschang Leticia Ferreira Pettenuzzo Eduardo von Pozzer Toigo Ana Cristina Andreazza Rachel Krolow Mônica Colpini Avila
Pharmacol Biochem Behav
November 2009
Caffeine is widely consumed in beverages and food, and its consumption in high doses is associated with anxiety increase. Stress situations are often associated to coffee consumption, and have a strong influence on oxidative DNA damage. As there are sex-specific differences in many metabolic, neurochemical and behavioral aspects, the aim of this study is to verify the interaction between chronic consumption of caffeine and chronic stress on anxiety and DNA breaks in the hippocampus on male and female rats.
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- The study examined how chronic caffeine intake affects oxidative stress in different brain regions of both stressed and non-stressed rats.
- Use of various caffeine concentrations (0.3 g/L and 1.0 g/L) revealed that caffeine increased the activity of some antioxidant enzymes in the brain, particularly in the cerebral cortex.
- However, these beneficial effects of caffeine on antioxidant enzyme activity did not occur in rats that were under repeated stress.