Publications by authors named "Monica C Nesselbush"
Profiling of circulating tumor DNA (ctDNA) in the bloodstream shows promise for noninvasive cancer detection. Chromatin fragmentation features have previously been explored to infer gene expression profiles from cell-free DNA (cfDNA), but current fragmentomic methods require high concentrations of tumor-derived DNA and provide limited resolution. Here we describe promoter fragmentation entropy as an epigenomic cfDNA feature that predicts RNA expression levels at individual genes.
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- Radiologic screening for high-risk adults can lower lung cancer mortality, but few eligible individuals in the U.S. actually get screened.
- The study enhances a method called CAPP-Seq, which analyzes circulating tumor DNA (ctDNA), showing that ctDNA is present in most early-stage lung cancer patients and can indicate prognosis.
- A new machine-learning tool, Lung-CLiP, accurately distinguishes early-stage lung cancer patients from similar-risk individuals, suggesting that using cfDNA in screenings could be beneficial in clinical settings.