Publications by authors named "Monica Bescos"
Article Synopsis
- - This study investigates the potential of urinary proteomic analysis as a noninvasive method to detect chronic allograft dysfunction (CAD) in kidney transplant patients, aiming to create a normal proteome map for stable transplant recipients.
- - Researchers collected urine samples from kidney transplant patients with varying stages of interstitial fibrosis and tubular atrophy, employing two-dimensional difference gel electrophoresis (2DE-DIGE) and mass spectrometry to analyze protein differences.
- - The findings identified a normal proteome consisting of plasma and immunologic proteins, with 19 proteins showing varying levels based on the severity of tissue damage, suggesting their potential use as urinary biomarkers for assessing CAD in renal transplant patients.
Background: Ischemia-reperfusion (IR) is a risk factor for delayed graft function, a clinical syndrome more frequently observed in non-heart-beating donors (NHBDs). Previous studies have reported that transforming growth factor-beta1 (TGF-beta1) and hypoxia-inducible factor-1alpha (HIF-1alpha) gene expression increase in the first few days after kidney transplant and that this increase in TGF-beta1 expression is lower in NHBD animals. The purpose of this study was to extend the gene profile analysis by characterizing TGF-beta1 activator thrombospondin-1 (TSP-1) and genes related to HIF-1alpha such as heme oxygenase-1 (HO-1), nitric oxide synthase-2 (NOS-2) and NOS-3.
View Article and Find Full Text PDFBackground: Ischemia-reperfusion syndrome has been recognized as an important pathogenic factor in renal transplantation, not only in the development of delayed graft function but also in the development of acute and chronic rejection. Hypoxia-inducible factor (HIF)-1 activates transcription of several genes implicated in cell survival, such as vascular endothelial growth factor (VEGF), and in tissue repair transforming growth factor (TGF)-beta. The purpose of this study was to characterize TGF-beta1, VEGF, and HIF-1alpha expression profiles during renal transplantation with heart-beating donors (HBD) and non-heart-beating donors (NHBD).
View Article and Find Full Text PDFHypertension and hyperfiltration are two important risk factors for the development of chronic allograft nephropathy. Transforming growth factor-beta(1) (TGF-beta(1)) is the main cytokine involved in the fibrotic process that is involved in chronic rejection. Angiotensin II upregulates TGF-beta(1) production.
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