A chromatin-regulated biphasic circuit coordinates IL-1β-mediated inflammation.

Inflammation is characterized by a biphasic cycle consisting initially of a proinflammatory phase that is subsequently resolved by anti-inflammatory processes. Interleukin-1β (IL-1β) is a master regulator of proinflammation and is encoded within the same topologically associating domain (TAD) as IL-37, which is an anti-inflammatory cytokine that opposes the function of IL-1β. Within this TAD, we identified a long noncoding RNA called AMANZI, which negatively regulates IL-1β expression and trained immunity through the induction of IL37 transcription.

Human scattered tubular cells represent a heterogeneous population of glycolytic dedifferentiated proximal tubule cells.

Scattered tubular cells (STCs) are a phenotypically distinct cell population in the proximal tubule that increase in number after acute kidney injury. We aimed to characterize the human STC population. Three-dimensional human tissue analysis revealed that STCs are preferentially located within inner bends of the tubule and are barely present in young kidney tissue (<2 years), and their number increases with age.

[Characteristics of Helicobacter pylori infection in a private hospital in Lima, 2019 experience and literature review].

Digestive diseases are the fourth leading cause of outpatient care in Peruvian healthcare centers, with gastritis and peptic ulcers being the most common. This is a retrospective, cross-sectional, descriptive study of secondary analysis of medical record data to evaluate the prevalence of Helicobacter pylori in patients undergoing upper digestive endoscopy during 2019 at Clinica Delgado, Lima, Peru. An association between males (PRa 1.

Emergence and outbreak of carbapenemase-producing KPC-3 Klebsiella pneumoniae in Spain, September 2009 to February 2010: control measures.

This report describes the epidemiological features of the first outbreak caused by KPC3 carbapenemase-producing Klebsiella pneumoniae (KPC-3-KP) in Spain and how it was effectively controlled. From 16 September 2009 to the end of February 2010, seven patients infected or colonised with KPC-3-KP were detected. Stool surveillance cultures were recovered from patients, doctors, nurses, nursing assistants, cleaners and hospital porters working in the affected units.

[Quality indicators in an intensive care unit: a two-year healthcare-associated infection surveillance program].

Objective: To estimate quality healthcare indicators in an intensive care unit (ICU).

Methods: A prospective observational study was conducted on all patients referred to the medical ICU of Ramón y Cajal hospital (Madrid) for more than 48 hours, from January 1 2008 to December 31 2009.

Results: A total of 503 patients were included, of whom 7.

Epidemiology of biological-exposure incidents among Spanish healthcare workers.

Objective: To determine the frequency and the epidemiological characteristics of biological-exposure incidents occurring among healthcare personnel.

Design: Prospective surveillance study.

Setting: Participating Spanish primary-care and specialty centers from January 1994 to December 1997.

Surgical antibiotic prophylaxis: effect in postoperative infections.

Objective: to assess the risk of surgical wound infection and hospital acquired infections among patients with and without adequate antibiotic prophylaxis. Also, to provide models to predict the contributing factors of hospital infection and surgical wound infection.

Design: survey study.

The burden of community-acquired pneumonia in Spain.

Background: Community-acquired pneumonia accounts for a large number of hospitalizations and deaths in developed countries.

Methods: Data for Spain were obtained from the national surveillance system for hospital data and comprises all hospital discharges for pneumonia reported during a two-year period.

Results: The annual incidence of hospitalization for pneumonia was 160 per 100,000 population.

Hospital admissions for pneumonia in Spain.

Background: Hospital-based surveillance study to estimate the burden of hospitalizations due to pneumonia in Spain.

Patients And Methods: The national surveillance system for hospital data (Conjunto Mínimo de Datos, CMBD) maintained by the Ministry of Health was used to obtain information concerning hospital discharges for pneumonia for the period January 1, 1995 to December 31, 1996.

Results: There were 109,644 hospitalizations for pneumonia during this period.

Nosocomial infections in Spain: results of five nationwide serial prevalence surveys (EPINE Project, 1990 to 1994). Nosocomial Infections Prevalence Study in Spain.

Objective: To determine trends in rates of nosocomial infections in Spanish hospitals.

Design: Prospective prevalence studies, performed yearly from 1990 through 1994.

Setting: A convenience sample of acute-care Spanish hospitals.

[Predictive factors of surgical infection in heart surgery].

Background: Deep infection of the surgical site in cardiac surgery may lead to very severe complications. There is controversy as to the importance which different factors may have in the incidence of this complication. The aim of this study was to determine the importance of determined factors on the risk of deep infection of the surgical site.

[Seroepidemiologic survey of hepatitis A antibodies in the young adult Spanish population. Spanish Study Group on hepatitis A (1)].

Background: The aim of the present was to study the rate of exposure to the hepatitis A virus (HAV) in the young adult Spanish population.

Methods: A transversal observational study was performed to evaluate the prevalence of anti-HAV antibodies (IgG) in a representative sample of the Spanish population between the ages of 20-40 years. Information on demographic variables (age, place of residence, education, number of children and number of brothers or sisters) and history of hepatitis was collected.

Nosocomial infections in pediatric patients: a prevalence study in Spanish hospitals. EPINE Working Group.

Background: The magnitude of the problem of nosocomial infection in children has never been studied in Spain.

Methods: In 1990, a nationwide cross-sectional study was conducted to determine the prevalence of nosocomial infection and associated risk factors.

Results: Among 38,489 patients surveyed, 4081 were pediatric patients.

[Periodic health examination].

A literature search has been made on the examinations to be performed during the "periodic health exam" on the healthy adult. These examinations shall be performed bearing in mind the prevalence and morbility data of the specific diseases, individual risk factors and the quality (sensibility and specificity) of the diagnostic procedure. The value of regular blood pressure determination, breast exam and cervical cytology with Papanicolaou stain, is well established.

Tobacco smoking, alcohol consumption, and laryngeal cancer in Madrid.

The associations between cigarette smoking and alcohol consumption and laryngeal cancer were examined in a case-control study carried out between 1982 and 1985 in Madrid. The analysis was based on 50 histologically confirmed male cases and 103 age- and sex-matched controls (45 hospitalized and 58 from the general population). A dose-response effect was observed for cigarette smoking, with an odds ratio (OR) of 4.