Publications by authors named "Monego S"
Introduction: In the process of bone regeneration, a prominent role is played by macrophages involved in both the initial inflammation and the regeneration/vascularization phases, due to their M2 anti-inflammatory phenotype. Together with osteoclasts, they participate in the degradation of the bone matrix if the inflammatory process does not end. In this complex scenario, recently, much attention has been paid to extracellular communication mediated by nanometer-sized vesicles, with high information content, called exosomes (EVs).
View Article and Find Full Text PDFIntroduction And Objectives: Epigenetic changes represent a mechanism connecting external stresses with long-term modifications of gene expression programs. In solid organ transplantation, ischemia-reperfusion injury (IRI) appears to induce epigenomic changes in the graft, although the currently available data are extremely limited. The present study aimed to characterize variations in DNA methylation and their effects on the transcriptome in liver transplantation from brain-dead donors.
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- * This study aimed to identify specific molecular changes in endothelial cells caused by factors found in the blood of COVID-19 patients.
- * The results showed that COVID-19 serum leads to increased cell death, loss of barrier function, and heightened clotting tendencies in endothelial cells, primarily through the activation of a receptor called PAR-2, suggesting it could be a target for future treatments.
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- High-throughput DNA sequencing has enabled in-depth characterization of the microbial populations in various parts of an organism, especially the gastrointestinal tract, which is important for understanding health and disease.
- Previous research on the fecal microbiome in dogs indicated variations due to dietary and sex factors, but direct comparison across studies is limited due to different methodologies and sample sizes.
- The current study aims to confirm earlier findings regarding diet's effect on fecal microbiome, explore the presence of bacteria in the blood of healthy dogs, and examine the potential link between fecal and blood microbiota, suggesting implications for diagnosing and preventing gut inflammatory diseases.
The discovery of circulating fetal DNA in the plasma of pregnant women has greatly promoted advances in noninvasive prenatal testing. Screening performance is enhanced with higher fetal fraction and analysis of samples whose fetal DNA fraction is lower than 4% are unreliable. Although current approaches to fetal fraction measurement are accurate, most of them are expensive and time consuming.
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- Early detection of bone erosion is crucial in managing rheumatoid arthritis and selecting appropriate treatments.
- This study introduces a measurable anatomical imaging biomarker derived from micro-CT imaging to indicate bone erosion in arthritis.
- Using a rat model and high-resolution micro-CT, researchers found that analyzing specific bone parameters improves data interpretation and evaluation of arthritis treatments.
Background: Germline mutations of the oncosuppressor gene breast cancer 1-associated protein 1 (BAP1) were recently related to an autosomal-dominant tumor predisposition syndrome (BAP1-TPDS), characterized by uveal melanoma, malignant mesothelioma (MM), cutaneous melanoma, and other malignancies. The demonstration that BAP1 mutations are strongly associated with MM has provided a real breakthrough in the study of genetic predisposition in MM, that may explain why only a fraction of asbestos-exposed individuals go on to develop MM.
Materials And Methods: To evaluate the possible role of BAP1 mutations in the epidemiology of sporadic MM, and their relationship with asbestos exposure, we determined the prevalence of germline BAP1 mutations by the Sanger method in a group of 29 asbestos-exposed patients, 21 of which were diagnosed with MM.