Fusobacterium nucleatum modulates the Wnt/β-catenin pathway in colorectal cancer development.

The Wnt/β-catenin signalling pathway normally maintains cellular and tissue homeostasis by regulating cellular differentiation and survival in a controlled manner. An aberrantly regulated Wnt/β-catenin signalling pathway can transform into an oncogenic pathway, which is associated with Colorectal cancer (CRC) as well as other cancers. CRC is one of the most frequently occurring gastrointestinal cancers worldwide.

Carbene-Functionalized Bulky-Cyclopentadiene Rings.

A series of significantly bulky mono- and di-substituted cyclic alkyl-amino carbene (cAAC)- functionalized cyclopentadiene ring (Cp) compounds were synthesized. The functionalization of the Cp ring with cAAC ligands makes them significantly bulkier, while retaining their ligation properties. These compounds display interesting fluorescence properties.

Effect of hydro-ethanol extract of Caesalpinia pulcherrima (L.) Sw. leaves in human and rat: In vitro approach of male contraceptive development.

Objective: The study focused the contraceptive efficacy of hydro-ethanolic (60:40) extract (HEE) of Caesalpinia pulcherrima leaves in human and rat sperm samples by in vitro study.

Methods: Six young fertile adult males were selected for semen collection. Sperm samples were collected from six adult rat also by chopping the epididymis along with the collection of testicles, epididymis, and liver.

Prognosis of Cardiovascular Conditions Noninvasively Using Printable Elastomeric Electronic Skin.

Lack of timely prognosis of cardiovascular condition (CVC) is resulting in increased mortality across the globe. Currently, available techniques are confined to medical facilities and need the intervention of specialists. Frequently, this impedes timely treatment, driven by socioeconomic factors.

Enhanced catalytic degradation of methylene blue using self-propelled Janus micromotors: An insight into decomposing characteristics of passive and active hematite particles studded with Pt nanoparticles.

Recent advancements in catalytic micromotors have shown significant potential for environmental applications, yet challenges such as particle agglomeration persist. In this study, we compare the degradation of methylene blue using hematite particles fully coated with platinum and those partially decorated with platinum. The selective decoration, confirmed through techniques like EDX, FESEM, TEM, and XPS, plays a crucial role in the micromotors' behavior.

Silylated Carbon Nanofiber/Polydimethylsiloxane Based Printable Electrorheological and Sensor Inks for Flexible Electronics.

Electrorheological fluids (ERF) have garnered significant attention for their potential to provide actuation on demand. Similarly, developing stimuli-responsive printable inks for flexible electronics is also gaining antecedence. However, developing a material that demonstrates both functionalities is far and few.

Immobilized Horseradish Peroxidase on Enriched Diazo-Activated Silica Gel Harnessed High Biocatalytic Performance at a Steady State in Organic Solvent.

Dimethyldichlorosilane (DMDCS), an efficient silane coupling reagent appearing between the -OH groups of silica gel (SG) and picric acid, instantaneously produces a derivative enriched with nitro groups. The nitro group acting as an end-cap terminates the reaction and subsequently was converted into diazo to couple tyrosine's phenol ring via its -carbon, the inert center to immobilize horseradish peroxidase (HRP) in a multipoint mode. It maintains the status quo of the native enzyme's protein folding and the entire protein groups' chemistry.

METTL3/MYCN cooperation drives neural crest differentiation and provides therapeutic vulnerability in neuroblastoma.

Neuroblastoma (NB) is the most common extracranial childhood cancer, caused by the improper differentiation of developing trunk neural crest cells (tNCC) in the sympathetic nervous system. The N-methyladenosine (mA) epitranscriptomic modification controls post-transcriptional gene expression but the mechanism by which the mA methyltransferase complex METTL3/METTL14/WTAP is recruited to specific loci remains to be fully characterized. We explored whether the mA epitranscriptome could fine-tune gene regulation in migrating/differentiating tNCC.

A distinctive and proficient fluorescent switch for ratiometric recognition of the menacing cyanide ion: biological studies on MDA-MB-231 cells.

A new fluorescent ratiometric switch (BOHB) was developed for swift and selective detection of cyanide ions in aqueous media without any interference from other competitive anions. Upon gradual addition of cyanide ions into the probe solution, a prominent fluorescence color change from yellow to cyan was observed under a UV chamber. The fluorescence changes thus observed were ratiometric, and the detection limit of this new probe was found to be (22.

Real World Outcomes with Treatment Free Remission in Chronic Myeloid Leukemia-Experience from a Tertiary Care Cancer Centre.

Chronic myeloid leukaemia (CML) is caused by balanced translocation t(9::22)(q34;q11) resulting in formation of pathogenic BCR-ABL fusion gene. Tyrosine kinase inhibitors (TKI) have revolutionised the treatment of CML. Ongoing treatment with TKI leads to side effects and has financial impact.

A validated heart-specific model for splice-disrupting variants in childhood heart disease.

Background: Congenital heart disease (CHD) is the most common congenital anomaly. Almost 90% of isolated cases have an unexplained genetic etiology after clinical testing. Non-canonical splice variants that disrupt mRNA splicing through the loss or creation of exon boundaries are not routinely captured and/or evaluated by standard clinical genetic tests.

A smart adaptable metal sequestering peptide conjugate to modulate Aβ fibrillar aggregation.

The aggregation of amyloid β peptide (Aβ) in the presence of elevated levels of transition-metal ions, , Fe, Cu, Zn, is accountable for enhanced cellular toxicity in Alzheimer's disease. Many strategies are reported to inhibit either Cu, Zn, or Fe-induced Aβ fibrillation, focused on one metal. Herein, a taurine-containing adaptable metal sequestering peptide (AMSP) has been developed as the modulator of any of the cited metal-induced Aβ-aggregation .

Long Stability of Atomically Precise Red Emissive Copper Nanoclusters within the Gel and Their Use As a Potential Catalyst and Fluorescent Ink.

Herein, an amphiphile-based hydrogel (with 5% DMF) containing natural amino acid residue has been used to prepare and stabilize red-emitting CuNCs for several months. Though different methods have been attempted, amphiphile and 4-mercaptobenzoic acid (4-MBA)-containing hydrogels are pinpointed to be the base medium to stabilize this new Cu-cluster. From a MALDI-TOF MS analysis it was found that it is a Cu-atom cluster stabilized by three 4-MBA ligands.

Elastomeric Sensor-Triboelectric Nanogenerator Coupled System for Multimodal Strain Sensing and Organic Vapor Detection.

Stretchable, flexible sensors are one of the most critical components of smart wearable electronics and Internet of Things (IoT), thereby attracting multipronged research interest in the last decades. Following miniaturization and multicomponent development of several sensors in one could further propel the demand for wireless, multimodal platforms. Greener substitutes to conventional sensors that can operate in a self-powered configuration are highly desirable in terms of all-in-one sensor utilities.

Effect of an Autotaxin Inhibitor, 2-(4-Chlorophenyl)-7-methyl-8-pentylimidazo[1,2-] Pyrimidin-5(8)-one (CBT-295), on Bile Duct Ligation-Induced Chronic Liver Disease and Associated Hepatic Encephalopathy in Rats.

The role of autotaxin (ATX)-lysophosphatidic acid (LPA) is yet to be explored in the context of liver cirrhosis and associated encephalopathy. Our objective of this study was to evaluate the role of an ATX inhibitor in biliary cirrhosis and associated hepatic encephalopathy in rats. The preliminary investigation revealed significant impairment in liver function, which eventually led to the development of hepatic encephalopathy.

Introduction and Effectiveness of Early Clinical Exposure Among Dental Students in Pre-clinical Prosthodontics.

Background: Lack of patient contact in the pre-clinical prosthodontics curriculum makes it difficult for the students to comprehend and correlate the series of complex steps involved in complete denture fabrication. Early clinical exposure in the second year of the undergraduate program will facilitate a smooth transition of dental students from pre-clinics to clinics, thereby helping to mitigate the lacunae existing in the present curriculum.

Materials And Methods: A non-randomized prospective educational interventional study was conducted among 50 second-year dental students.

Eco-friendly and sustainable approaches against aphids management () and dissipation studies of imidacloprid in important cash crop capsicum under protected and open condition.

Capsicum is generally infested with many biotic agents mainly sucking insects, among them the major is aphid (. Chemical management is one of the most common strategies for their management. However, there are no recommended insecticides for insect management in polyhouse.

Electrokinetic particle trapping in microfluidic wells using conductive nanofiber mats.

The frequency dependence of electrokinetic particle trapping using large-area (>mm) conductive carbon nanofiber (CNF) mat electrodes is investigated. The fibers provide nanoscale geometric features for the generation of high electric field gradients, which is necessary for particle trapping via dielectrophoresis (DEP). A device was fabricated with an array of microfluidic wells for repeated experiments; each well included a CNF mat electrode opposing an aluminum electrode.

Polyurethane/Carbon Nanotube-Based ThermoSense Electronic Skin: Perception to Decision Making Aided by Internet of Things Brain.

Human skin has several receptors collaborating with the brain to provide appropriate "decisions" when applying stimuli. Several research articles state that biomimetic electronic skin (e-skin) is reportedly used for sensor-related applications and performs similarly to natural skin. However, research reporting the capability of the e-skin to make decisions and therefore react upon exposure to adverse conditions is still in its nascent stage.

Hysteresis-Free Temperature Sensing with Printable Electronic Skins Made of Liquid Polyisoprene/CNTs.

Developing an electronic skin (e-skin) is becoming popular due to its capability to mimic human skin's ability to detect various stimuli. Mostly, such skins are tactile-based sensors. However, the exploration of nontactile-based sensing capability in the e-skin is still in a nascent stage.

Activation of Inert Supports for Enzyme(s) Immobilization Harnessing Biocatalytic Sustainability for Perennial Utilization.

Although Nature's evolution and intelligence have gifted humankind with noteworthy enzyme candidates to simplify complex reactions with ultrafast, overselective, effortless, mild biological reactions for millions of years, their availability at minute-scale, short-range time-temperature stability, and purification costs hardly justify recycling/or reuse. Covalent immobilization, particularly via multipoint bonds, prevents denaturing, maintains activities for long-range time, pH, and temperature, and makes catalysts available for repetitive usages; which attracts researchers and industries to bring more immobilized enzyme contenders in science and commercial progressions. Inert-support activation, the most crucial step, needs appropriate activators; under mild conditions, the activator's functional group(s) still present on the activated support rapidly couples the enzyme, preventing unfolding and keeping the active site alive.

Elastomeric Ionic Hydrogel-Based Flexible Moisture-Electric Generator for Next-Generation Wearable Electronics.

Rapid consumption of traditional energy resources creates utmost research interest in developing self-sufficient electrical devices to progress next-generation electronics to a level up. To address the global energy crisis, moisture-electric generators (MEGs) are proving to be an emerging technology in this field, capable of powering wearable electronics by harvesting energy from abundantly available ambient moisture without any requirement for external/additional energy. Recent advances in MEGs generally utilize an inorganic, metal, or petroleum-based polymeric material as an active material, which may produce sufficient current but lacks the flexibility and stretchability required for wearable electronics.