Publications by authors named "Monalisa Sarma"

Article Synopsis
  • Zolbetuximab is a chimeric monoclonal antibody designed to target the Claudin 18.2 protein, which is overexpressed in certain gastrointestinal cancers, notably gastric and gastroesophageal junction adenocarcinomas.
  • This drug initiates an immune response to attack cancer cells when combined with standard chemotherapy regimens, and it has been approved as a first-line treatment for advanced, unresectable cancers in specific patient populations.
  • Clinical trials show that zolbetuximab significantly improves progression-free survival and overall survival rates compared to chemotherapy alone, while maintaining a relatively safe profile for patients.
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Background: In the realm of neuro-disorders, precise diagnosis and treatment rely heavily on objective imaging-based biomarker identification. This study employs a sparsity approach on resting-state fMRI to discern relevant brain region connectivity for predicting Autism.

New Method: The proposed methodology involves four key steps: (1) Utilizing three probabilistic brain atlases to extract functionally homogeneous brain regions from fMRI data.

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In response to a stimulus, distinct areas of the human brain are activated. Also, it is known that the regions interact with one another. This functional connectivity is helpful to diagnose any neurological abnormality, such as autism spectrum disorder (ASD).

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In the domain of neuroergonomics, cognitive workload estimation has taken a significant concern among the researchers. This is because the knowledge gathered from its estimation is useful for distributing tasks among the operators, understanding human capability and intervening operators at times of havoc. Brain signals give a promising prospective for understanding cognitive workload.

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Motor imagery (MI) based brain-computer interface systems (BCIs) are highly in demand for many real-time applications such as hands and touch-free text entry, prosthetic arms, virtual reality, movement of wheelchairs, etc. Traditional sparse representation based classification (SRC) is a thriving technique in recent years and has been a successful approach for classifying MI EEG signals. To further improve the capability of SRC, in this paper, a weighted SRC (WSRC) has been proposed for classifying two-class MI tasks (right-hand, right-foot).

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EEG-Based Mental Workload Estimation.

Annu Int Conf IEEE Eng Med Biol Soc

July 2019

Knowledge of the level of mental workload induced by any task is essential for optimizing load share among the operators. This helps in assessing their capability; besides, helping in task allocation. Since a persistently high workload experienced by operators such as aircraft pilots and automobile drivers many times compromises their performance and safety.

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Vigilance or sustained attention is defined as the ability to maintain concentrated attention over prolonged time periods. It is an important aspect in industries such as aerospace and nuclear power, which involve tremendous man-machine interaction and where safety of any component/system or environment as a whole is extremely crucial. Many methods for vigilance detection, based on biological and behavioral characteristics, have been proposed in the literature.

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In the present data article we report the in vitro and in vivo biocompatibility of fabricated nerve conduits described in Das et al. [1]. Green synthesised gold nanoparticles (GNPs) were evaluated for their cytotoxicity in rat Schwann cells (SCTM41).

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Article Synopsis
  • A new silk-gold nanocomposite nerve conduit was tested on rats with severe sciatic nerve injuries, showing promising results after 18 months.
  • The conduit, made by electrospinning silk fibers coated with gold nanoparticles, encouraged the growth of Schwann cells and was non-toxic, leading to better nerve regeneration.
  • Pre-seeding the conduits with Schwann cells significantly improved myelination and nerve function, as evidenced by strong motor unit potentials and enhanced animal movement.
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