Publications by authors named "Monalisa Navare"
Parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra leading to disabling deficits. Dopamine neuron grafts may provide a significant therapeutic advance over current therapies. We have generated midbrain dopamine neurons from human embryonic stem cells and manufactured large-scale cryopreserved dopamine progenitors for clinical use.
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- * These RG-like cells demonstrate typical characteristics and behavior of normal RG, existing in both dormant and active states, as shown through single-cell RNA sequencing.
- * The study highlights the role of interleukins in stimulating these cells to transition from dormancy to active division, suggesting inflammation may influence tumor growth and indicating that RG cells might play a role in tumor initiation and maintenance.