Neurofilament light chain: a new marker for neuronal decay in the anterior chamber fluid of patients with glaucoma.

Background/aims: Neurofilament light chain (NfL) levels in cerebrospinal fluid and serum are reliable indicators for neuroaxonal damage in a broad spectrum of neurodegenerative diseases. Herein, we investigate NfL levels in serum and anterior chamber fluid of patients with glaucoma.

Methods: Patients scheduled for routine glaucoma or cataract surgery were recruited for this study.

Influence of single-fraction Gamma-Knife radiosurgery on ocular surface and tear function in choroidal melanoma patients.

Aim: To evaluate ocular surface and tear function in patients with choroidal melanoma treated with single-fraction radiosurgery.

Methods: 36 patients (median age 62 years; range 26-84 years) were enrolled between 2001 and 2006 at a single institution. They were treated with the Leksell Gamma Knife in one fraction with a median dose of 30 Gy (range 25-35 Gy).

Visual acuity after Gamma-Knife radiosurgery of choroidal melanomas.

Background/aims: To report on conservation of visual acuity after Gamma-Knife radiosurgery of choroidal melanoma.

Methods: A total of 189 patients with choroidal melanoma were treated with Gamma-Knife stereotactic single-fraction radiosurgery at a single institution between June 1992 and May 2010. The main outcome measure of our retrospective analysis was conservation of pretreatment visual acuity of 20/40 or better, 20/200 or better and counting fingers (CF) or better, over time of follow-up.