Urinary miRNA-377 and miRNA-216a as biomarkers of nephropathy and subclinical atherosclerotic risk in pediatric patients with type 1 diabetes.

Background: Urinary microRNAs (miRNAs) play a role in the pathogenesis of chronic kidney disease (CKD).

Aim: To identify the expression of urinary miR-377 and miR-216a in 50 children and adolescents with type 1 diabetes (T1DM) compared with 50 healthy controls and assess their relation to the degree of albuminuria, glycemic control and carotid intimal thickness (CIMT) as an index of atherosclerosis.

Methods: Diabetic subjects were divided into normoalbuminuric and microalbuminuric groups according to urinary albumin creatinine ration (UACR).

Plasma osteoprotegerin concentrations in type 1 diabetic patients with albuminuria.

Background: Osteoprotegerin (OPG) is a recently identified inhibitor of bone resorption. Recent studies indicate that OPG is also associated with endothelial dysfunction in diabetes.

Aim: To investigate the relationship between plasma OPG levels and urinary albumin excretion (UAE) in type 1 diabetes.